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Definition: Why is maintaining protein quality control important for healthy aging?
Protein quality control refers to the cellular mechanisms that ensure the proper folding, assembly, and degradation of proteins. These mechanisms play a crucial role in maintaining cellular homeostasis and preventing the accumulation of damaged or misfolded proteins.As individuals age, the efficiency of protein quality control systems tends to decline, leading to an increased risk of protein aggregation and the formation of toxic protein aggregates. This decline in protein quality control can contribute to the development of age-related diseases, such as neurodegenerative disorders like Alzheimer’s and Parkinson’s disease.
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Protein aggregates can disrupt cellular processes, impair organelle function, and induce cellular stress responses. They can also trigger inflammation and oxidative stress, further exacerbating the aging process. Therefore, maintaining protein quality control is crucial for healthy aging and the prevention of age-related diseases.
Efforts to enhance protein quality control mechanisms through lifestyle interventions, such as regular exercise and a balanced diet, as well as pharmacological interventions, are being explored as potential strategies to promote healthy aging and delay the onset of age-related diseases.
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Keywords: protein, quality, control, cellular, maintaining, healthy, mechanisms, related, diseases










