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Why are senescent cells targeted in age intervention?

Senescent cells secrete a range of molecules and factors, collectively known as the senescence-associated secretory phenotype (SASP), which can have detrimental effects on surrounding cells and tissues. The SASP includes pro-inflammatory cytokines, growth factors, and matrix remodeling enzymes, among others.

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Targeting senescent cells in age intervention has gained significant attention in recent years due to their potential role in promoting aging and age-related diseases. By selectively eliminating senescent cells, researchers aim to delay or reverse the aging process and improve healthspan.

There are several approaches being explored to target senescent cells. One approach is the use of senolytic drugs, which are compounds that selectively induce apoptosis (cell death) in senescent cells. Another approach is the use of senescence-inducing therapies, which aim to induce senescence in specific cells, such as cancer cells, to prevent their proliferation.

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Studies have shown that the removal of senescent cells in animal models can lead to improved healthspan, delayed onset of age-related diseases, and increased lifespan. However, more research is needed to fully understand the mechanisms underlying senescence and develop effective interventions targeting senescent cells in humans.

Keywords: senescent, senescence, related, diseases, intervention, growth, tissues, associated, process