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What is the role of DNA methylation in cellular senescence?

DNA methylation, on the other hand, is an epigenetic modification that involves the addition of a methyl group to the DNA molecule. It plays a crucial role in gene regulation and cellular identity.

Recent research has shown that DNA methylation patterns undergo significant changes during cellular senescence. These changes can affect the expression of genes involved in various cellular processes, including cell cycle regulation, DNA repair, and inflammation.

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One of the main findings is that DNA methylation tends to increase in senescent cells, leading to the silencing of certain genes. This can contribute to the loss of cell functionality and the development of age-related phenotypes.

Moreover, DNA methylation changes during cellular senescence are not random but rather occur at specific genomic regions. For example, there is evidence that DNA methylation alterations are enriched in regions known as CpG islands, which are often found near gene promoters.

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Overall, the role of DNA methylation in cellular senescence is complex and multifaceted. It is involved in the regulation of gene expression and can contribute to the functional decline of senescent cells. Understanding the mechanisms underlying DNA methylation changes during cellular senescence may provide insights into the aging process and potential therapeutic targets for age-related diseases.

Keywords: methylation, cellular, senescence, changes, related, regulation, during, various, process