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Effects of Caloric Restriction Mimetics on Inflammation

One of the key mechanisms through which caloric restriction mimetics exert their beneficial effects is by modulating inflammation. Inflammation is a natural immune response that helps the body fight against infections and injuries. However, chronic low-grade inflammation, also known as inflammaging, is associated with aging and age-related diseases such as cardiovascular disease, neurodegenerative disorders, and cancer.

Caloric restriction mimetics have been shown to reduce chronic inflammation by targeting various molecular pathways involved in the inflammatory response. These pathways include the nuclear factor-kappa B (NF-κB) pathway, the mammalian target of rapamycin (mTOR) pathway, and the sirtuin pathway.

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NF-κB is a transcription factor that plays a central role in regulating the expression of genes involved in inflammation. Caloric restriction mimetics can inhibit NF-κB activity, thereby reducing the production of pro-inflammatory cytokines and chemokines.

The mTOR pathway is a nutrient-sensing pathway that regulates cell growth and metabolism. Activation of mTOR is associated with increased inflammation. Caloric restriction mimetics can inhibit mTOR signaling, leading to reduced inflammation.

Sirtuins are a family of proteins that regulate various cellular processes, including inflammation. Caloric restriction mimetics can activate sirtuins, which in turn suppress inflammation by deacetylating and modifying the activity of key transcription factors involved in the inflammatory response.

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In addition to modulating these pathways, caloric restriction mimetics can also enhance the body’s antioxidant defenses, which further contribute to their anti-inflammatory effects. By reducing oxidative stress and inflammation, caloric restriction mimetics may help prevent or delay the onset of age-related diseases.

Overall, the effects of caloric restriction mimetics on inflammation are promising in the context of longevity and healthspan. Further research is needed to fully understand the mechanisms underlying these effects and to determine the optimal dosage and duration of treatment. However, these compounds hold great potential as therapeutic interventions for promoting healthy aging and preventing age-related diseases.

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Keywords: inflammation, caloric, restriction, mimetics, effects, pathway, related, diseases, inflammatory