John Krasinski and Natalie Portman are on the hunt for the real-life Fountain of Youth in the films new trailer.

Directed by Guy Ritchie, and a script penned by James Vanderbilt, the story is about two siblings who reconnect to embark on an adventure of a lifetime to acquire immortality.

In the trailer, Krasinskis character Luke hesitantly calls up his sister Charlotte to enlist her help to find the long sought-after, once thought to be mythological Fountain of Youth. Are you in trouble? During a phone call with Luke, Portmans character asks before asserting, You only call when youre in trouble. The film also stars Eiza Gonzlez and Domhnall Gleeson as they seek adventure that spans five continents, dozens of cultures, over thousands of years, Krasinskis character states in the trailer. Additional cast includes Arian Moayed, Laz Alonso, Carmen Ejogo and Stanley Tucci.

Skydance Media produced the film for Apple in a first-look deal alongside Vinson Films and Project X Entertainment. David Ellison, Dana Goldberg, Don Granger, Tripp Vinson, William Sherak, Paul Neinstein, Ritchie, Ivan Atkinson and Jake Myers produce, while Radio Silences Matt Bettinelli-Olpin, Tyler Gillett and Chad Villella serve as executive producers.

Notably, Fountain of Youth will arrive on the heels of Apple and Sykdance joining forces for the action-horror hybrid The Gorge, which starred Miles Teller and Anya-Taylor Joy; the horror film Mayday, with Ryan Reynolds and Kenneth Branagh; and The Family Plan, led by Mark Wahlberg.

Fountain of Youth will debut via Apple TV+ on May 23.