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Definition: How does lomitapide impact lipid metabolism?

Lomitapide works by inhibiting the microsomal triglyceride transfer protein (MTP), which is responsible for the assembly and secretion of lipoproteins, including LDL-C, in the liver and intestines. By inhibiting MTP, lomitapide reduces the production and release of LDL-C into the bloodstream.

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In addition to its effects on LDL-C, lomitapide also impacts other aspects of lipid metabolism. It has been shown to decrease the levels of triglycerides, very low-density lipoprotein cholesterol (VLDL-C), and apolipoprotein B (apoB), which are all markers of increased cardiovascular risk.

Furthermore, lomitapide has been found to increase the levels of high-density lipoprotein cholesterol (HDL-C), commonly known as “good cholesterol.” HDL-C plays a crucial role in reverse cholesterol transport, which involves the removal of excess cholesterol from peripheral tissues and its transport back to the liver for excretion.

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Overall, lomitapide’s impact on lipid metabolism is multifaceted. It reduces the production and release of LDL-C, decreases triglyceride levels, and increases HDL-C levels. These effects contribute to the overall improvement in lipid profile and cardiovascular risk reduction in individuals with HoFH.

Keywords: lomitapide, cholesterol, levels, metabolism, density, lipoprotein, cardiovascular, impact, inhibiting