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Definition: How do senolytic therapies impact the overall health and lifespan of an individual?

Senolytic therapies are a class of interventions that target and eliminate senescent cells, which are cells that have entered a state of irreversible growth arrest and are no longer functioning properly. These therapies have gained significant attention in the field of longevity research due to their potential to improve healthspan and extend lifespan.

Impact on Overall Health

Senescent cells accumulate in various tissues and organs throughout the body as a person ages. These cells secrete a range of harmful molecules, known as the senescence-associated secretory phenotype (SASP), which can promote chronic inflammation and disrupt tissue homeostasis. By selectively targeting and removing senescent cells, senolytic therapies aim to reduce the burden of SASP and restore tissue function.

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The removal of senescent cells has been shown to have several positive effects on overall health. Studies in animal models have demonstrated that senolytic interventions can improve cardiovascular function, enhance lung function, restore kidney function, and ameliorate age-related metabolic dysfunction. Additionally, senolytics have been found to alleviate age-related frailty and improve physical performance.

Impact on Lifespan

While the primary goal of senolytic therapies is to improve healthspan, there is also evidence to suggest that these interventions may have the potential to extend lifespan. Animal studies have shown that senolytic treatments can delay the onset of age-related diseases and extend the lifespan of mice. These effects have been observed in various tissues and organs, indicating a systemic impact on aging.

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The mechanisms through which senolytic therapies extend lifespan are still being investigated. It is believed that the removal of senescent cells reduces the burden of chronic inflammation and cellular dysfunction, thereby delaying the onset of age-related pathologies and extending the overall lifespan.

In conclusion, senolytic therapies have the potential to significantly impact the overall health and lifespan of individuals. By targeting and eliminating senescent cells, these interventions can improve tissue function, reduce chronic inflammation, and delay the onset of age-related diseases. Further research is needed to fully understand the long-term effects of senolytic therapies on lifespan extension.

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Keywords: senolytic, lifespan, senescent, impact, improve, function, related, health, interventions